What is Lean and Fab?
Lean
and Fab is a safe, natural and effective weight loss and weight
management dietary supplement in the market today harnessing natural
US-patented ingredients and is currently the only highly documented
supplement because of the numerous clinical trials done for its
development.
Lean and Fab boasts of six major
revolutionary simultaneous actions in the body, it breaks down fat,
increases Lean Body Mass, burns fat, safely suppresses appetite, blocks
extra calorie absorption and increases the bioavailability of nutrients
for better absorption in the body.
Natural Ingredients:
ForsLean
is manufactured by a proprietary process and is a standardized extract
from the roots of the Coleus forskohlii plant, the only known plant
source of forskohlin.
What is ForsLean?
01.ForsLean is manufactured by a
proprietary process and is a standardized extract from the roots of the
Coleus forskohlii plant, the only known plant source of forskohlin.
ForsLean
is a registered trademark of Sabinsa Corporation and is the only Coleus
forskohlii preparation supported by US Patent # 5,804,596 defined as
"….a method of preparing a forskohlin composition…and use of forskohlin
for promoting lean body mass and treating mood disorders" . Canadian,
European and Japanese patents are pending. Companies or individuals
using any Coleus forskohlii preparation other than ForsLean รข in their
respective product formulations, which suggest, imply or represent their
products to promote lean body mass, fat loss and weight loss are
infringing on Sabinsa's use patent for forskohlin.
Intended Application
The importance of maintaining or
regaining lean body mass has recently come to light for two important
reasons. First is the increased recognition that lean body mass plays a
vital role in any successful weight training regimen, and second, there
is a growing awareness that lean body mass is proportionate to the
overall health of an individual.
Lean body mass is composed of
muscle, vital organs, bone and bone marrow, connective tissue and body
water. The percentage of lean body mass to fat not only determines the
body's aesthetic appearance, but more importantly, it is also an index
of physical fitness, health status, susceptibility to disease and
premature mortality. Because the body's metabolic rate is directly
proportional to the amount of lean body mass, there is substantial
interest in products that safely increase lean body mass because they
are most likely to work. The use of ForsLean may help to increase lean
body mass and optimize body composition with one of the side effects
being fat loss and/or weight loss.
A sluggish metabolic rate is
an undesired effect of many weight-loss regimens. It was observed in one
study that formerly obese subjects had a 3-5% lower resting metabolic
rate than control subjects. The occurrence of a low resting metabolic
rate is likely to contribute to the high rate of weight regain in
formerly obese persons.
Clearly, we need to change and broaden
our thinking on the objectives of weight management regimens for both
active and not-so-active individuals. In particular, it should be
emphasized that healthy functioning of the body depends not so much on a
lower fat content, but rather on obtaining a higher percentage of lean
body mass. Again, it should be kept in mind that it is not only fat, but
also lean body mass that is, or can be, lost through dieting. This fact
often escapes our attention when we reduce our total body weight. The
loss of lean body mass offsets any benefits derived from the reduction
of body weight, and can potentially increase one’s chances for diabetes,
cardiovascular disease and possibly some forms of cancer due to poor
metabolic activity.
Mechanism of Action
"ForsLean shifts the proportion between
lean body mass and adipose, or fatty, tissue in favor of lean body
mass, which improves overall health," explains Vladimir Badmaev, MD,
PhD, Sabinsa Corporation’s Vice President, Scientific and Medical
Affairs. "The effect can be measured by decreases in the waist hip ratio
and the body mass index."
The mechanism of action on how
ForsLean works is well defined (see attached stapled diagrams). Badmaev
adds, "Forskohlin, the active compound in ForsLean, is recognized as
an adenylate cyclase activator. Adenylate cyclase is the enzyme involved
in the production of cyclic adenosine monophosphate (cAMP), a
significant biochemical agent in metabolic processes. The role of cyclic
AMP is indispensable to many body functions. It induces a chain
reaction of biochemical events that trigger metabolic processes and diet
induced thermogenesis, thereby providing the means to maintain healthy
body composition and lean body mass levels."
Proof of Efficacy Summary
ForsLean was tested in an open-field
study with a population of six overweight women (BMI>25). The tested
formula was in the form of two-piece, hard shell capsules; each capsule
contained 250 mg of ForsLean. The overweight, but otherwise healthy
women, received one capsule twice daily for eight weeks. Participants
were instructed to take one capsule in the morning and one in the
evening, half an hour before a meal. Each participant was asked to
maintain her previous daily physical exercise and eating habits. In
addition, physical activity was monitored based on a questionnaire
before and during the trial.
During the eight week trial, the
mean values for body weight and fat content significantly decreased,
whereas lean body mass was significantly increased as compared to the
baseline. Neither the systolic/diastolic blood pressure, nor the pulse
rate was adversely affect during the trial. Indeed, a trend was observed
of lower systolic/diastolic pressure during the course of treatment. A
line graph is attached that shows actual results from this study.
Dosage form/delivery
ForsLean has been clinically evaluated
at one dose, 250 mgs twice daily. This provides 50 mgs of forskohlin,
the primary active compound in ForsLean. Dosage has been in the form of
a two piece, hard shell capsule.
Sabinsa also offers standardized Coleus forskohlii extracts in concentrations of 1%, 20%, 40% and 95% forskohlin.
Additional information of interest
Currently two new studies have been
undertaken to further explore the efficacy of ForsLean, one in the US
and the other in Japan. Prior to these two studies, both LD50 analysis
and AMES test were performed by independent laboratories in the US
confirming the safe use of ForsLean
The US study is underway at
the University of Memphis, Exercise & Sports Nutrition Laboratory.
Twenty mildly obese female subjects between the ages of 18 to 40 have
been recruited to participate in this study.
The study is
designed as a double blind, placebo-controlled investigation of
ForsLean versus a similarly matched placebo for 12 weeks. After
baseline testing, subjects will be randomly assigned to ingest 2
capsules a day containing either ForsLean® or the placebo. (one capsule
in the morning and one in the evening, half an hour before a meal). Each
active capsule contains 250 mg of ForsLean®.
Analysis for this
trial includes the overall assessment of select parameters, blood
pressure, body composition and individual serological and hematological
profiles. Subjective questionnaires to determine the subjects’
perception of the treatment and quality of life/lifestyle aspects will
also be administered.
Dr. Tsuguyoshi Asano, a prominent Tokyo
based Japanese physician who specializes in Internal medicine and
bariatrics is the principle investigator in a 12-week study protocol
including 20 overweight, but otherwise healthy, men and women who have a
body mass index (BMI) 25-26. 250 mgs of ForsLean® will be administered
twice a day in the form of a two-piece hard shell capsule. Each
participant will receive a physical examination, and their blood
biochemistry and body composition will be analyzed at the inception and
after 4, 8 and 12 weeks of the study. ForsLean® has been cleared for
nutritional use by the Japanese FDA.
As mentioned in the
beginning, with Sabinsa’s discovery of the lean body mass/weight loss
properties of forskohlin, which was not a traditional use of the herb,
the US Patent and Trademark Office granted to Sabinsa a use patent for
this compound. This is not an achievement to be lightly passed over.
02.GarCitrin
is a standardized extract obtained from the dried fruit rinds of
Garcinia cambogia and it is standardized for minimum 50% (-)
Hydroxycitric acid and minimum 5% Garcinol.
GarCitrin is a standardized extract obtained from the dried fruit
rinds of Garcinia cambogia and it is standardized for minimum 50% (-)
Hydroxycitric acid and minimum 5% Garcinol.
Chemistry of GarCitrin:
GarCitrin contains (-)HCA and Garcinol.
Pharmacology of HCA - the key active ingredient of Citrin range of products
The
fat regulating mechanism of Hydroxycitrate (HCA) was uncovered when
scientists were scrutinizing different steps of Krebs cycle.
Biosynthesis
of fatty acids takes place naturally in the Krebs Cycle by the
following mechanism.Glycolysis breaks the glucose into pyruvate.
- Pyruvate decarboxylates to give Acetyl CoA in mitochondria.
- Oxaloacetate combines with Acetyl CoA to form Citrate in the mitochondria.
- Citrate moves into Cytoplasm and is converted to Acetyl CoA with help of citrate lyase.
- Acetyl CoA is converted to Malonyl CoA and further it forms Fatty Acids.
Hydroxycitrate (HCA) competes with Citrate to produce outcomes that offer significant benefit in weight management.
1. HCA promotes inhibition of fat synthesis
HCA inhibit enzyme Citrate lyase involved in synthesis of malonyl CoA, a precursor for fatty acid synthesis.
2. HCA promotes fat oxidation:
- HCA has 100 times greater affinity for Citrate Lyase, hence it acts as a potent inhibitor of Citrate Lyase.
- Because of its inhibition, very little Acetyl CoA reaches cytoplasm.
- This in turn limits the activity of Malonyl CoA.
- Lower levels of Malonyl CoA activates L-carnitine transferase
- Fatty acids are transported into
mitochondria by linking it with L-carnitine. This linking is facilitated
by L-carnitine transferase.
- Hence the oxidation of fatty acids is stimulated.
- Ability of HCA to promote fat loss in humans result primarily from stimulation of fat oxidation.
3. Suppression of Appetite by HCA:
HCA provides a sense of satiety to the
user and this has been clinically found in our various Citrin trials.
Increase in fat metabolism by HCA in liver stimulates
gluconeogenesis-glycogen storage in liver. High level of glycogen is
signaled by CNS as a state of satiety and a decreased food intake.The
activation of fat oxidation by Hydroxycitrate in liver also tends to
stimulate gluconeogensis.
- Pyruvate carboxylase initiate a chain of reactions that converts pyruvate into Glucose.
- This replenishes the stored Glycogen storage in liver.
- The high level of Glycogen, as a result of high glucose supply is translated by CNS as a state of satiety.
Amplibio Effect of GarCitrin:
Amplibio
refers to a mechanism wherein either one of the compounds serves to
facilitate the biological effect of other compounds or as a result, both
biological activities are enhanced.
It was hypothesized that
composition comprising HCA in combination with garcinol would be more
absorbable and bioavailable to the body and to the individual cells than
HCA administered alone resulting in higher rate of the competitive
inhibition of ATP citrate lyase and more efficient use as a weight-loss
therapy.
The Amplibio action of the HCA/garcinol combination
would work hypothetically by the anti-oxidant action neutralizing
negative charges surrounding the cell to facilitate transport and uptake
of HCA into the cell, by affecting fluidity of cell membranes to
facilitate transport and uptake of HCA into the cell, and by synergy
with HCA to inhibit citrate lyase, thus lowering the threshold for such
inhibition with the HCA.
03.Fabenol
is an alpha-amylase inhibitory natural extract obtained from Phaseolus
vulgaris (common bean, kidney bean) that blocks the digestion of dietary
starch, thereby offering potential benefits in the maintenance of
healthy blood sugar levels and optimal body composition.
Fabenol
is an alpha-amylase inhibitory natural extract obtained from Phaseolus
vulgaris (common bean, kidney bean) that blocks the digestion of dietary
starch, thereby offering potential benefits in the maintenance of
healthy blood sugar levels and optimal body composition.
The emergence of obesity as the leading
public health problem in the United States is a matter of great concern.
Over 58 million adults in the U.S. are obese and about one in five
American children and adolescents is overweight. Obesity greatly
increases the risk of premature death, and it is a major risk factor for
developing chronic conditions such as diabetes, heart disease, high
blood pressure, gallbladder disease, arthritis, lung problems and some
of the more common forms of cancer. According to government statistics,
obesity accounts for about three hundred thousand premature deaths in
the United States each year.
The increased incidence of obesity
is attributed to improper diet and a sedentary lifestyle. Therefore the
quality of our lives depends upon appropriate lifestyle choices. We have
to shed down our excess weight if we want to lead a happy life.
Reduction of fat storage / overweight of individuals requires much and
prolonged effort. Diet restrictions and extreme exercise regimens have
poor success rates in weight reduction. However, smart nutritional
choices supplemented with natural weight management products in
combination with appropriate exercise regimens would serve the purpose.
Excess
carbohydrates in the diet are ultimately converted to fats and stored
in the body. In both plants and animals, starch is broken down by
amylases and maltase to yield glucose. Plants break down starch during
seed germination or tuber sprouting to supply the energy and carbon
skeletons. Animals and fungi break down plant starch to obtain glucose
for their own metabolism. The enzymes that catalyze the conversion of
starch (a polysaccharide) into sugar molecules (monosaccharides) are
called amylases. Surprisingly, plants usually contain amylase inhibitory
compounds in the same organs (seeds and tubers) where the starch is
stored, to ward off bacterial, fungal and animal predators. No parallels
exist in mammalian systems.
Currently, scientists focus their
interest on the amylase inhibitors produced by plants to block amylase
activity in the human digestive tract. An amylase inhibitor acts as an
antinutrient that obstructs the digestion of starch and absorption of
glucose. Therefore amylase inhibitors are therapeutically valued in
conditions such as diabetes (to reduce blood sugar levels) and in weight
management. One of the conventionally used drugs in the management of
diabetes, Acarbose, is a complex oligosaccharide that delays the
digestion of ingested carbohydrates, thereby resulting in a smaller rise
in blood glucose concentration following food intake. Acarbose inhibits
the action of pancreatic amylase in breaking down starch, thereby
achieving this effect.
04. BioPerine
is the only product sourced out of piperine to obtain a patented status
for its ability to increase the bioavailability of nutritional
compounds. Secondly, it is the only source from piperine to have
undergone clinical studies in the U.S. to substantiate its safety and
efficacy for nutritional use.
BioPerine is the only product sourced
out of piperine to obtain a patented status for its ability to increase
the bioavailability of nutritional compounds. Secondly, it is the only
source from piperine to have undergone clinical studies in the U.S. to
substantiate its safety and efficacy for nutritional use.
Is a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper).
Contains 95 percent of piperine.
May be co-administered with various nutrients for both human and animal health.
Is Nature's Bioavailability Enhancing Thermonutrient.
If
you lack the one ingredient that can change the way your body looks,
just go for BioPerine. Get more for your body from this supplement.
How does BioPerine work?
The
metabolic process that generates energy at the cellular level in the
human body is called thermogenesis. Though thermogenesis has been
identified as a key factor in maintaining weight loss, it has also been
identified as playing an integral role in utilizing the daily food and
nutrients that the human body consumes. It sets in motion the mechanisms
that lead to digestion and subsequent gastrointestinal absorption.
Piperine, in the patented form of BioPerine enhances the body's natural
thermogenic activity-hence the term Thermonutrient.
This
enhancement may be explained as a means of increasing the thermal energy
sufficient to "power up" the mechanism related to thermogenesis. This
in turn results in increased metabolic processes that creates a "demand"
for "supply" of a broad range of nutrients that contribute to
metabolism, i.e. vitamins, minerals, herbals, amino acids, etc. It is as
if BioPerine activates a metabolic paddle wheel, of sorts, that
selectively provides a more efficient mode of nutrient transportation
into the blood.
The Advantages of BioPerine BioPerine is the
only product sourced out of piperine to obtain a patented status for
its ability to increase the bioavailability of nutritional compounds.
Secondly, it is the only source from piperine to have undergone clinical
studies in the U.S. to substantiate its safety and efficacy for
nutritional use.
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